What is the FDA limit for titanium dioxide?
The most significant uncertainty identified by the EU experts was the concern that TiO2 particles may have genotoxic effects. Genotoxicity refers to the ability of a chemical to directly damage genetic material within a cell (DNA), which may lead to cancer in certain situations. Although the experts did not conclude that TiO2 particles in E171 are genotoxic, they could not rule out the concern that they might be.

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Most commonly used in candy, it can also be found in salad dressings, chewing gum, ice cream, frozen pizzas, drink and jello mixes and many other food categories. Titanium dioxide creates a smooth finish and adds shine and brightness to other colors.
Often used as a glaze for ceramics, titanium dioxide provides a bright, glossy finish and improves the durability and stain resistance of ceramic products.
Algaecidal effect of Lithopon: After 5 years of exposure to weathering in Alpen (Lower Rhine)


Recent policy changes in regard to titanium dioxide
In addition to Skittles, other candies that contain titanium dioxide include Nice! mints, Trolli sour gummies and Ring Pops, according to Environmental Working Group.
Animal studies have shown that, when consumed as a food additive, titanium dioxide can induce intestinal inflammation.
Titanium dioxide goes into many industrial and consumer products. It makes paper white and bright, it keeps plastics and rubber soft and flexible, and helps remove harmful emissions from car exhaust, among many other uses. In the drug industry, it's a key ingredient in pill capsules and tablet coatings to keep the medicine inside from being affected by sunlight.